As of January 10, Peterborough City Hospital has recorded 300 deaths related to Covid-19 since March.
Caroline Walker, chief executive for North West Anglia NHS Foundation Trust, said: "I can confirm that sadly, 427 patients being cared for in our Trust have passed away since we began reporting Covid-19-related deaths.
"There have been 127 at Hinchingbrooke Hospital and 300 at Peterborough City Hospital. All patients were aged 30 to 98 years old and the majority of those had pre-existing health conditions. We are currently caring for 198 patients with Coronavirus in our hospitals.
"Our thoughts and condolences remain with the patients' families and loved ones at this difficult time."
The latest figures came on Sunday, when England’s chief medical officer Professor Chris Whitty warned that the NHS is facing the "most dangerous situation" in living memory, and said the only way to prevent avoidable deaths is for the public to stay at home wherever possible.
Statistics from last week showed that as of January 5, there were 14 patients in North West Anglia hospitals in Mechanical Ventilation (MV) beds. These numbers have fluctuated daily, but there haven't been fewer than 5 MV beds in use at the Trust since November 13. From August 16 to September 9 there were no patients using these beds.
Professor Adam Finn, a member of the Joint Committee on Vaccination and Immunisation (JCVI) said the vaccine rollout will already have prevented thousands of people from having to be admitted to hospital with the virus.
The Professor of Paediatrics at the University of Bristol told Sky News’ Sophy Ridge: "It’s really too soon for the vaccine to have started having a measurable impact, but we can predict that already it’s preventing cases just simply from the numbers of people who’ve received the vaccine which is now approaching one-and-a-half million people, and the rate of infection that’s occurring which is really very high now.
"So there are certainly thousands of people already who have not been admitted to hospital and who will not be dying of this infection as a consequence of the programme that’s begun in December."