The second lane of the parkway will be closed between junctions 3A (to the A605) and 5 (Boongate) for two weeks from Monday September 20.
This is to carry out repairs to the crash barrier, which is deteriorating in sections and no longer complies with current standards.
Resurfacing works are also planned southbound between junctions 8 and 3 (from the Eye junction to the Nene Parkway junction) from Monday October 4 until Monday November 1.
This work will be carried out overnight - the road will be closed between 8pm and 6am on weekdays only.
Motorists are being warned that congestion is likely, especially during peak traffic hours.
Cllr Peter Hiller, cabinet member for strategic planning, said: “Closing a road is always something we try to avoid, but these repairs are of vital importance.
“Our parkways and barriers are over 40 years old and, with hugely increased traffic volumes over that period, they require regular and timely maintenance and safety improvements.
“Our highways team will be working day and night to get the road open again, and the full closure will keep them safe as they carry out this important work.
“I would like to thank everyone for their understanding and would strongly urge that they plan ahead as there is likely to be congestion when the scheme begins.”