The shop will be moving into a vacant unit formerly used by Mothercare, which closed in November 2019.
Excited shoppers reported seeing staff stocking shelves at the shop in preparation for tomorrow.
This is the second Superdrug store in Peterborough. The first one is based in Queensgate shopping centre.
Apart from Superdrug, two more new retailers will be moving into Serpentine Green including JD Sports. The opening date for JD sports is yet to be announced, although branding and boarding have gone up in preparation for an opening soon.