Having been forced to postpone the 2020 and 2021 events, the Cambridge Rock Festival will make its comeback at the Peterborough venue from June 16-19.
The festival began in 2004 and is now approaching its 17th year.
Up to 100 bands will appear on three stages over four days. Some are local acts, but national and international bands have also appeared.
Bands confirmed for 2022 include Cambridgeshire's own Austin Gold, along with Solstice, Cats in Space and The Pure Floyd Show.
Fundraising collections will be held on each day of the festival to help local charities. In 2016, the festival was extended a day to help raise money for Addenbrooke's Hospital.
Ian Stuart, press officer for the festival, said: "The aim has always been to provide great entertainment and avoid the corporate nature of many larger festivals as far as possible.
"All the proceeds from ticket and drink sales go to help fund the event rather than pay the organisers.
"We are especially proud of the fact that we never have a problem with rubbish as everything is kept tidy by our volunteer stewards."
Volunteer stewards are being sought for next year's festival, as are sponsors for the event.